Primary cutaneous diffuse large B cell lymphoma (other) C85.1

Group of very rare, large cell lymphomas of the skin that are not localized to the legs (other) and are therefore not included in the significantly more common large cell cutaneous B-cell lymphomas of the leg (see below Primary cutaneous diffuse large B-cell lymphoma leg type). They are addressed as a separate entity. This group also includes morphologic variants of diffuse large B-cell lymphoma, such as anaplastic or immunoplastic subtypes and T-cell-rich or histiocyte-rich large B-cell lymphomas. See"Diffuse large B-cell lymphoma" (Internal Medicine).

Primarily radiotherapy, if necessary excision (in case of solitary occurrence).

Alternative: Interferon alfa (low dose) or monoclonal anti-CD20 AK ( Rituximab).

Alternative: polychemotherapy (e.g. CHOP regimen).

In nodal large B-cell lymphomas, combination therapy of CHOP and rituximab proved superior to CHOP therapy alone in terms of remissions and overall survival in large numbers of cases.

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