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Premalignant fibroepitheliomaC44.L

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 01.02.2022

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Synonym(s)

Basal cell carcinoma; basal cell carcinoma fibroepithelial; fibroepithelial; Fibroepithelial tumor; fibroepithelioma of pinkus; Fibroepithelioma Pinkus; Fibroepithelioma (Pinkus); Pinkus tumor; premalignant fibroepithelial tumor of the skin; Premalignant fibroepithelioma

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HistoryThis section has been translated automatically.

Pinkus, 1953

DefinitionThis section has been translated automatically.

Histologically and immunohistologically defined variant of superficial basal cell carcinoma with pronounced stromal development.

Recent studies suggest an intermediate stage between basal cell carcinoma and trichoblastoma. Both tumors originate from the same cell type but differ in differentiation.

LocalizationThis section has been translated automatically.

Mainly lumbosacral, lower abdomen, inguinal and inner thigh area.

Clinical featuresThis section has been translated automatically.

Single or several, usually flat raised, skin-coloured or delicately reddened, moderately rough, 0.5-2.0 cm plaques, rarely ulceration.

HistologyThis section has been translated automatically.

Network of fine epithelial strands, only a few cell layers thick, filled with dense, connective tissue stroma. In numerous places bud-like epithelial outgrowths with palisade position of the marginal cells. Immunohistologically, the tumorous epithelial tumor parts do not express PHLDA1, an expression behavior characteristic of basal cell carcinoma.

Differential diagnosisThis section has been translated automatically.

Verruca seborrhoica; fibroma.

TherapyThis section has been translated automatically.

Corresponding to superficial basal cell carcinoma. Excision in sano. If necessary also curettage and after-treatment with 5-fluorouracil ointment(e.g. Efudix) once/day for 3-5 days under occlusion.

Progression/forecastThis section has been translated automatically.

Inexpensive, curable by excision in sano.

LiteratureThis section has been translated automatically.

  1. Deichmann M et al (2003) Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas). J Cutan Pathol 30: 363-368
  2. Pinkus H (1953) Premalignant fibroepithelial tumors of the skin. Arch Dermatol Syph 67: 598-615.
  3. Sellheyer K et al (2012) Fibroepithelioma of Pinkus is a true basal cell carcinoma developing in association with a newly identified tumour-specific type of epidermal hyperplasia. Br J Dermatol. 166):88-97
  4. Tarallo M et al (2011) Fibroepithelioma of Pinkus: variant of basal cell carcinoma or trichoblastoma? Case report. G Chir 32:326-328
  5. Haddock ES et al (2016) Fibroepithelioma of Pinkus Revisited. Dermatol Ther (Heidelb). 6: 347-362
  6. Bowen AR et al (2005) Fibroepithelioma of pinkus is a fenestrated trichoblastoma Am J Dermatopathol 27:149-154.

Authors

Last updated on: 01.02.2022

Author: Prof. Dr. med. Peter Altmeyer