Porphyria cutanea tarda: Acquired PCt with unusual clinical presentation: extensive skin damage to both backs of the hands with blistering at the edges.
Porphyria cutanea tarda: detailed picture; the variety of skin lesions can be reduced to certain features by careful analysis.
Porphyria cutana tarda: discrete finding with which the disease initially presents itself. after banal traumas subclinical blisters develop. here residuals with erosions and shallow ulcerations
Porphyria cutanea tarda: close-up. older scars marked by stars. vertical arrows: encrusted erosions after traumta; vertical arrows: bulging (subepithelial - the entire epidermis forms the firm bladder roof) fresh areactive blisters (the blisters appear as if from nowhere. no signs of inflammation!)
porphyria cutanea tarda. shown here is a detailed picture of the hand with an overall generalized, chronically dynamic infection on the integument of a 55-year-old man. on the right hand, hemorrhagic blisters appear a few hours old next to older, crusty erosions and flat atrophic, somewhat depigmented scars. the blisters appear after banal everyday traumas. the blistering is combined with hyperpigmentation in the face and neck (melanodermic porphyria brugsch) and hypertrichosis lanuginosa of the zygomatic arch.
Porphyria cutanea tarda: back of the hand and dorsal forearms with small papules, excoriations and older scars and hyperpigmentation. no fresh blisters. palms free of irritation.
Porphyria cutanea tarda: Pronounced scarring in the area of the forearms and back of the hand in a patient on dialysis (for years extremely light skin vulnerability).
Porphyria cutanea tarda. extensive erosions and crusts with "normal" healing tendency in a 60-year-old patient with known chronic hepatopathy. clear signs of actinic damage to the capillitium. similar HV were found on forearms and back of the hand.
Porphyria cutanea tarda. strong fluorescence phenomena of both the dermoepidermal junction zone (linear fluorescence at the upper edge of the picture) and the dermal vessels (note the papillary bodies). such phenomena are found in Porphyria cutanea tarda as well as in chronic dialysis. staining with a fibrinogen antibody
Porphyria cutanea tarda: detail view with linear deposits of fibrinogen at the basement membrane (vertical arrows). distinct fluorescence of capillary vessels in the papillary dermis (stars). bar indicates the depth of the reteleal ridge. epithelium is fluorescent here.
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