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Porokeratotic eccrine ostiumnaevusD22.9

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 15.08.2022

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Synonym(s)

PEODDN; Porokeratotic eccrine and ostial dermal duct naevus

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HistoryThis section has been translated automatically.

Marsden, 1979

DefinitionThis section has been translated automatically.

Rare hamartoma with eccrine differentiation (see also Hamartoma, eccrine), which clinically resembles comedone nevus, but occurs preferentially on the palms and soles, where pilosebaceous follicles are absent. It is a cornification disorder involving the intraepidermal ductus eccrinus (acrosyringium), characterized in pathology by an eccrine hamartoma and a cornoid lamella.

ManifestationThis section has been translated automatically.

Male and female sexes are equally affected.

LocalizationThis section has been translated automatically.

Especially the lower extremities, palms of the hands and soles of the feet are affected. Rarely located on the trunk.

Clinical featuresThis section has been translated automatically.

Asymptomatic, yellowish or yellow-brownish, hyperkeratotic papules and plaques arranged in the Blaschko lines. Frequently interspersed are firmly adherent "comedone-like" keratoses.

HistologyThis section has been translated automatically.

When magnified, clear epidermal intussusceptions with prominent hyperkeratosis, acanthosis and parakeratosis become apparent. In places ampoule-like enlargement of acrosyringies with focal parakeratosis. The glandular part of the eccrine apparatus is not affected.

TherapyThis section has been translated automatically.

If necessary, excision. Otherwise conservative care.

Case report(s)This section has been translated automatically.

The 29-year-old patient noticed pruritic skin lesions on the right lateral malleolus for 8 years. Pathological examination revealed multiple small epidermal invaginations with overlying parakeratotic cornoid lamellation, loss of granular layer, and few dyskeratotic cells at the base of the epidermal invagination. After clinicopathologic correlation, a diagnosis of porokeratotic eccrine ostial and dermal duct nevus (PEODDN) was made (see Fig.).

LiteratureThis section has been translated automatically.

  1. Chowdhary B et al (2019) Porokeratotic Eccrine Ostial and Dermal Duct Nevus and Porokeratotic Eccrine and Hair Follicle Nevus: Is Nomenclature "Porokeratotic Adnexal Ostial Nevus" More Appropriate? Indian Dermatol Online J 10:478-480.
  2. Levinsohn JL et al.(2014) A Somatic p.G45E GJB2 Mutation Causing Porokeratotic Eccrine Ostial and Dermal Duct Nevus. JAMA Dermatol 151:638-641.
  3. Marsden RA et al (1979) Comedo naevus of the palm - a sweat duct naevus? Br J Dermatol 101: 717-722.
  4. Murphy LA et al (2004) Porokeratotic eccrine and ostial dermal duct naevus. Clin Exp Dermatol 29: 333-334
  5. Naraghi MM et al (2013) Porokeratotic eccrine ostial and dermal duct nevus. Case Rep Dermatol Med:953840.
  6. Vasudevan B et al.(2015) A unique association of unilateral idiopathic calcinosis cutis with ipsilateral porokeratotic eccrine ostial and dermal duct nevus. Pediatr Dermatol 32:e8-12.

Authors

Last updated on: 15.08.2022

Author: Prof. Dr. med. Peter Altmeyer