Plexiform fibrohistiocytic tumor

Enzinger and Zhang 1988

Preferably in children and young adults, fibro-myofibroblastically differentiated, slowly but locally aggressively growing, rarely metastatic, cutaneously-subcutaneously localized, painless tumor.

Children and young adults, also appearing at a later age.

Tumor parenchyma arranged in baths and fascicles from fibroblastically or myofibroblastically differentiated spindle cell formations. Interspersed are epithelioid or histiocytic cells with multinucleated giant cells. Mitoses are rare. Also myxoid or fibrous sections. The tumor cells are immunoreactive for vimentin, CD68; negative for S-100 protein and pancytokeratin.

Excision with sufficient safety distance (danger of recurrence).

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2. Harrill JC et al (2014) Plexiform fibrohistiocytic tumor of the foot: a case report. J Foot Ankle Surgery 53:635-637.
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