Piroxicam

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Non-steroidal anti-inflammatory drug from the Piroxicame group.

Indication
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Pain with arthritis, including rheumatoid arthritis, ankylosing spondylitis, pain with arthrosis or other underlying diseases.

Dosage and method of use
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  • Topical: Gel/Cream: Apply 3-4 times/day approx. 1 g and massage in.
  • Systemic: Tbl/injection method: Initial for 2 days: 20-40 mg in 1-2 doses p.o. or 20 mg once/day i.m. Subsequently (also as initial dose for lighter cases): 2 times/day 10 mg p.o. or once/day 20 mg p.o. or once/day 20 mg i.m.

Standard concentration
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0.5% in ointments or gel.

Undesirable effects
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  • Common (10-20% of patients): Gastrointestinal symptoms such as heartburn, loss of appetite, nausea, vomiting, abdominal pain.
  • Occasionally (1-10% of patients): Cutaneous side effects such as maculopapular exanthema, urticaria. Occasional increase in transaminases (in rare cases hepatitis or pancreatitis).
  • Rarely (about 5% of patients: fatigue, paresthesia, dizziness).

Contraindication
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Children/adolescents < 18 years. Hypersensitivity to the substance or cross-reactions to other non-steroidal anti-inflammatory drugs ( including acetylsalicylic acid ). Active stomach or intestinal ulcers, gastrointestinal bleeding. Severe liver or kidney failure.

Preparations
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Felden, Piroxicam-ratiopharm, Felden top cream, Felden top gel

Note(s)
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Remember! The ability to react in road traffic and when operating machines may be impaired!

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Last updated on: 29.10.2020