DefinitionThis section has been translated automatically.
Immunosuppressive agent for the treatment of mild to moderate idiopathic pulmonary fibrosis (IPF)
EffectsThis section has been translated automatically.
Pirfenidone is a small molecule active substance that can be taken orally. It inhibits the synthesis of several cytokines that are involved in inflammatory and fibrotic processes. For example, it inhibits the transforming growth factor TGF-beta. TGF-beta controls numerous cell functions, including proliferation and differentiation. The cytokine plays a key role in the development of fibrosis. Pirfenidone also inhibits the synthesis of TNF-alpha, a cytokine that is actively involved in inflammatory processes.
Trade namesThis section has been translated automatically.
Esbriet
Note(s)This section has been translated automatically.
Contraindication is severe liver or kidney dysfunction. Side effects affect the gastrointestinal tract (dyspepsia, nausea, diarrhea, GERD (Gastroesophageal reflux desease). Photosensitivity is also observed (direct UV exposure should be avoided).
Prof. Dr. med. Peter Altmeyer