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Autoantibodies of the IgG and/or IgA class against structures of intercellular contacts, in particular desmosomal components in the epidermis. To date, both cadherins (calcium-dependent, transmembrane adhesion molecules) and intracellular proteins of desmosomal plaques have been identified as autoantigens. See also pemphigus.
Prof. Dr. med. Peter Altmeyer