DefinitionThis section has been translated automatically.
Painful secondary pannicultitis of the subcutaneous fatty tissue with calcium deposits, which is due to calciphylaxis.
Occurrence/EpidemiologyThis section has been translated automatically.
Rarely and almost without exception in dialysis patients (prevalence approx. 1%); in individual cases in chronic alcohol abuse.
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EtiopathogenesisThis section has been translated automatically.
Terminal renal failure, secondary or tertiary hyperparathyroidism; insufficient hemodialysis (exceeding the solubility limit for calcium and phosphate in the blood).
LocalizationThis section has been translated automatically.
Mainly occurring on the abdomen or the front of the thighs.
Clinical featuresThis section has been translated automatically.
Livedo, erythematous nodules, often necrotizing and progressive until the development of torpid ulcers; often superinfections; occasionally varicosis and acrocyanosis.
LaboratoryThis section has been translated automatically.
Electrolytes, parathormone, calcitonin, vitamin D3 hormone.
HistologyThis section has been translated automatically.
Detection of calcification in the adipose tissue lobules as well as in the septa of the adipose tissue. Frequent single cell necrosis, sometimes confluent to larger fat cysts with basophilic debris and calcification. Mediavercalcification and intimal hyperplasia of the small arterial vessels.
DiagnosisThis section has been translated automatically.
Difficult, because often overlaid by other clinical pictures. Laboratory, histology.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
Treatment of the underlying disease, haemodialysis, if necessary necrosis removal and skin reconstruction
Progression/forecastThis section has been translated automatically.
Poor, despite treatment (mortality approx. 80%).
Diet/life habitsThis section has been translated automatically.
Low phosphate diet.
LiteratureThis section has been translated automatically.
- Lim SP (2003) Calciphylaxis in a patient with alcoholic liver disease in the absence of renal failure. Clin Exp Dermatol 28: 34-36
- Milas M (2003) Calciphylaxis and nonhealing wounds: the role of the vascular surgeon in a multidisciplinary treatment. J Vasc Surgery 37: 501-507
- Schwarz G et al (2000) Calciphylaxis: ischemic tissue necrosis in chronic renal failure. dermatologist 51: 36-40
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Outgoing links (5)
Crest syndrome; Cryoglobulins and skin; Livedo (overview); Lupus erythematosus (overview); Scleroderma (overview);Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer