P53 protein

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.08.2021

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DefinitionThis section has been translated automatically.

The p53 protein is a tumor suppressor protein and is detectable as an accumulated protein in numerous tumors (see also tumor suppressor genes). The coding gene(TP53 gene) (TP53 is the acronym for tumor protein 53) is located on the short arm of chromosome 17 (17p13.1) in humans. The gene spans 20 kb, with a non-coding exon 1 and a very long first intron of 10 kb. TP53 orthologs have been identified in most mammals for which complete genome data are available.

LiteratureThis section has been translated automatically.

  1. Barbosa K et al.(2019) The role of TP53 in acute myeloid leukemia: challenges and opportunities. Genes Chromosomes Cancer 58:875-888.

  2. Hantschke M et al (2016) Immunohistochemical techniques. In: L. Cerroni et al. Histopathology of the skin. Springer Verlag Berlin-Heidelberg p. 31.

  3. Jiao XD et al. (2018) The prognostic value of TP53 and its correlation with EGFR mutation in advanced non-small cell lung cancer, an analysis based on cBioPortal data base. Lung Cancer123:70-75.

Authors

Last updated on: 29.08.2021

Author: Prof. Dr. med. Peter Altmeyer