DefinitionThis section has been translated automatically.
Class of antibiotics with an antibacterial spectrum of action against gram-positive pathogens.
Pharmacodynamics (Effect)This section has been translated automatically.
- Inhibition of bacterial protein synthesis by specific binding to the 23S rRNA of the 50S subunit of bacterial ribosomes and alteration of the formymethionine transfer (fmet-tRNA) binding site. This results in the formation of a non-functional 70S initiation complex.
- Oxazolidinones do not act by inhibiting peptidyltransferase, but block bacterial protein synthesis even before the elongation phase, in which antibiotics such as chloramphenicol or macrolides have their pharmacological approach. Therefore, cross-resistances with other antibiotic drug classes are rare.
Prof. Dr. med. Peter Altmeyer