Nitrofurantoin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 15.09.2022

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Definition
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Chemotherapy drug.

Half-life
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0,3–0,5 h

Spectrum of action
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Citrobacter spp., Enterobacter spp., Enterococcus faecalis, E. coli, Klebsiella spp., Proteus spp., Providencia spp., Serratia spp., Staphylococcus spp.

Indication
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Treatment and prophylaxis of uncomplicated urinary tract infections.

Dosage and method of use
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4 times 0.05-0.15 g/day p.o.

Undesirable effects
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Nausea, vomiting, liver dysfunction, cholestasis, lung changes to pulmonary fibrosis, allergic reactions, BB changes, polyneuropathy, dizziness, headache.

Interactions
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Prevention of absorption by magnesium salts, delayed absorption by simultaneous food intake.

Contraindication
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Pregnancy, lactation, infants up to 3 months of age, oliguria, renal failure, hemolytic anemia, hepatitis, pulmonary fibrosis, polyneuritis, glucose-6-phosphate dehydrogenase deficiency, polyneuropathy.

Preparations
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furadantine, uro-tablines, nifurantine

Note(s)
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Induction of a sweet syndrome after ingestion of nitrofurantoin has been described.

Literature
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  1. Callen JP et al (2002) Neutrophilic dermatoses. Dermatol Clin 20: 409-441

Outgoing links (1)

Sweet syndrome;

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Last updated on: 15.09.2022