Neonatal toxic-shock-like exanthematous diseaseL50.9

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

NTED

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HistoryThis section has been translated automatically.

Takahashi, 1998

DefinitionThis section has been translated automatically.

A clinical picture reminiscent of " toxic shock syndrome" caused by methicillin-resistant strains of S. aureus ( MRSA), which form the superantigen "toxic shock syndrome toxin-1". The vast majority of patients described so far have been observed in Japan.

EtiopathogenesisThis section has been translated automatically.

Triggered by TSST-1-forming MRSA. The massive expansion of certain T cells leads to the release of excessive amounts of cytokines.

ManifestationThis section has been translated automatically.

In newborns.

Clinical featuresThis section has been translated automatically.

Already in the first weeks of life development of erythroderma with thrombopenia.

DiagnosisThis section has been translated automatically.

Hospital, MRSA detection.

TherapyThis section has been translated automatically.

If necessary, antibiotics after antibioogram.

Progression/forecastThis section has been translated automatically.

Usually within one week spontaneous remission. Maternal IgG anti-TSST-1 antibodies seem to have a protective effect.

LiteratureThis section has been translated automatically.

  1. Kikuchi K et al (2003) Molecular epidemiology of methicillin-resistant Staphylococcus aureus strains causing neonatal toxic shock syndrome-like exanthematous disease in neonatal and perinatal wards. J Clin Microbiol 41: 3001-3006
  2. Nakano M et al (2002) An outbreak of neonatal toxic shock syndrome-like exanthematous disease (NTED) caused by methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit. Microbiol Immunol 46: 277-284
  3. Okada Y et al (2004) Ilio-psoas abscess caused by methicillin-resistant Staphylococcus aureus (MRSA): a rare but potentially dangerous condition in neonates. Pediatric Surgery Int 20: 73-74
  4. Takahashi N (2003) Neonatal toxic shock syndrome-like exanthematous disease (NTED). Pediatric Int 45: 233-237
  5. Takahashi N et al (1998) Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period. Lancet 351: 1614-1619

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer