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Nasal papilla fibrosusD23.3

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Fibrous facial papule; Fibrous Papule; Fibrous papule of the nose; nasal fibrosis; nasal nodular fibrosis; nodular fibrosis nasi

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HistoryThis section has been translated automatically.

Graham et al. 1965

DefinitionThis section has been translated automatically.

Harmless, flat, up to lens-sized papules, usually located at the tip of the nose.

EtiopathogenesisThis section has been translated automatically.

Probably regressively altered melanocytic nevus, which some authors regard as fibroma.

ManifestationThis section has been translated automatically.

In larger studies (n=283) the mean age (at the time of diagnosis) was 46 years (18-90 years). No gender preference.

LocalizationThis section has been translated automatically.

Mainly tip of the nose and nostrils.

Clinical featuresThis section has been translated automatically.

Solitary, rarely multiple, completely painless, up to 0.5 cm in size, usually firm, hemispherical, surface smooth, skin-coloured to light reddish, flat, inconspicuous papules.

HistologyThis section has been translated automatically.

Irregularly pigmented epidermal band with numerous bright cells in the stratum basale. Infiltrate consisting of epithelioid cells and single bizarrely configured giant cells in the upper corium. Connective tissue proliferation with perifollicular emphasis.

6 histological variants are distinguished:

  1. cell-rich
  2. inflammatory
  3. pleomorph
  4. pigmented
  5. clear-cell
  6. granular cell

Except for the clear cell type, all forms express Factor XIIIa

Differential diagnosisThis section has been translated automatically.

TherapyThis section has been translated automatically.

If necessary, tangential ablation of the papules to slightly below the skin level; alternatively or complementary cauterization or abalative laser (this method requires great clinical experience of the surgeon).

LiteratureThis section has been translated automatically.

  1. Altmeyer P (1977) The fibrous nasal papules - a clinical and histological entity? Dermatologist 28: 416-420 de Cambourg G et al (2013) Fibrous papules of the face: a retrospective anatomoclinical study of 283 cases. Ann Dermatol Venereol 140:763-770
  2. Graham JH et al (1965) Fibrous papule of the nose: a clinicopathological study. J Invest Dermatol 45: 194-203
  3. Roth W et al (1990) Nasal nodular fibrosis, Sutton nevus and dermatofibroma in oil paintings by famous artists. Dermatologist 41: 406-407
  4. Shea CR et al (1996) CD34-reactive fibrous papule of the nose. J Am Acad Dermatol 35: 342-345

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer