Naevus melanocytic deep infiltrating D22.-

Seab JA Jr et al. 1989

Rare, benign tumor of melanocytes, which is clinically characterized by blue - or blue-black nodules (reminiscent of a blue nevus). The diagnosis can only be made histologically.

mainly women < 50 years

Head, neck region, shoulder, upper and lower extremities, rarely on the sole of the foot

0.5 - max. 2.0 cm in size, blue or blue-black, moderately firm, symmetrically exophytic, papules/nodes with smooth surface structure.

Towards the depth rather asymmetrical melanocytic tumour formations which can penetrate the dermis in a wedge shape. Infestation of the subcutis possible. There is a fascicular-plexiform pattern. The cell type is spindly or epitheloid. Sectional groups of melanophages. To the depth the maturing diminution of the cells can be missing. Occasionally, dermal mitoses are also found, as well as a focal lymphocytic infiltrate (Luzar et al.). Rare is the detection of melanocyte nests in the junctional zone (junctional activity). A perineural arrangement is possible.

1. Bergman R et al (2015) A deep penetrating facial congenital melanocytic tumor with bone involvement and ipsilateral eye blindness. On J dermatopath. 37:e5-e11.
2. Luzar B et al (2011) Deep penetrating nevus: a review. Arch Pathol Lab Med. 135:321-326.
3. Seab JA Jr et al (1989) Deep penetrating nevus. Am J Surg Pathol 13: 39-44
4. Strazzula L et al (2014) The deep penetrating nevus. J Am Acad Dermatol 71:1234-1240.
5. Veronese E et al (2016) Deep penetrating nevus on the sole of the foot: case report and dermatological features. J Dtsch Dermatol Ges 14:516-518