Mycosis fungoides granulomatous C84.0

Histological variant of mycosis fungoides (about 6% of all patients with mycosis finmgoides) with formation of epitheloid cell granulomas reminiscent of sarcoidosis or anular granuloma.

In larger (partly retrospective) studies, there was no clinical difference between the classical mycosis fungoides and the granulomatous variant.

There is an atypical lichenoid CD4(+) CD8(-) lymphocytic infiltrate with interstitial histiocytes and/or perivascular epithelial cell granulomas with giant cells (partly sarcoid aspect). Eosinophilic granulocytes and plasma cells are added to the infiltrate. Nuclear atypia and the detection of clonality of the T cell population consolidate the diagnosis.

S.u. Mycosis fungoides (overview)

Apparently, this subtype of mycosis fungoides is associated with a worse prognosis than the classical form, both with regard to the response to therapy and the 5- and 10-year progression-free survival rate. However, the overall survival rate is the same between both groups.

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