Mycosis fungoid tumor stage C84.0

Most common (about 50% of all CTCL), chronic progressive, phased, primarily cutaneous T-cell lymphoma (indolent, low malignant T-cell lymphoma), which originates from CD4-positive, small to medium-sized T-cells (T-helper lymphocytes).

• tumor stage ("tumor stage"):
• Combination pattern of large red patches, red scaly plaques and formation of nodules in lesional skin; these have a strong tendency to ulceration.
  • Increasing severe itching, especially in affected skin.
  • Non-specific and specific lymph node infestation (biopsy necessary).
  • The involvement of internal organs increases with increasing tumor load.
  • Increasing significant disturbance of the general condition.
  • Tendency to septic bacterial and viral infections.
• Accompanying symptoms of mycosis fungoides:
  • Mucosal involvement: Possible in every phase; especially of the oral mucosa, tongue, tonsils, nasal cavities, pharynx.
  • Organ involvement: Involvement of the spleen, liver, lungs, gastrointestinal tract or CNS in very late stages of the tumour. Skeletal involvement missing.

Clinical data of further illustrations and therapy see below Mycosis fungoides (overview).

1. Bosisio FM et al (2015) Expression of T-follicular helper markers in sequential biopsies of progressive mycosis fungoides and other primary cutaneous T-cell lymphomas. At J Dermatopathol 37:115-121
2. Hodak E et al (2014) Response to: "Tumor stage mycosis fungoides in nonblood-related family members". J Am Acad Dermatol 71:1002-1003
3. Nath SK et al (2014) Poorer prognosis of African-American patients with Mycosis fungoides: an analysis of the SEER dataset, 1988 to 2008 Clin Lymphoma Myeloma Leuk 14:419-423
4. Quaglino P et al (2012) Time course, clinical pathways, and long-term hazards risk trends of disease progression in patients with classic mycosis fungoides: a multicenter, retrospective follow-up study from the Italian Group of Cutaneous Lymphomas. Cancer 118:5830-5839
5. Yamada Y et al (2013) Complete clinical remission of tumor-stage granulomatous mycosis fungoides after treatment with PUVA, skin electron irradiation, oral etretinate and systemic interferon-γ. Int J Dermatol 52:893-895