Multiple endocrine neoplasia 2A D44.8

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 24.11.2022

Synonym(s)

MEN-2a; MEN-2a syndrome; MEN Type IIa; Multiple endocrine adenomatosis type IIa; sickle syndrome

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HistoryThis section has been translated automatically.

Sipple, 1961

DefinitionThis section has been translated automatically.

Disease belonging to the multiple endocrine neoplasms (OMIM 171400) with a combination of pheochromocytoma (possibly bilateral), medullary thyroid carcinoma, and possibly parathyroid adenoma, cutaneous lichen amyloidosus and Hirschprung's disease associated.

EtiopathogenesisThis section has been translated automatically.

Autosomal-dominantly inherited; mutation of the RET prooncogene, a gene coding for a transmembrane tyrosine kinase, which is mapped on chromosome 10q11.2

LiteratureThis section has been translated automatically.

Breza J Jr et al (2018) Multiple endocrine neoplasia 2A (MEN 2A) syndrome. Bratisl Lek Listy119:120-125.
Mathiesen JS et al (2022) Multiple endocrine neoplasia type 2: A review. Semin Cancer Biol 79:163-179
Sipple JH (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31: 163-166
Verga U et al (2003) Frequent association between MEN 2A and cutaneous lichen amyloidosis. Clin Endocrinol (Oxf) 59: 156-161.

Authors

Last updated on: 24.11.2022

Author: Prof. Dr. med. Peter Altmeyer