Synonym(s)
MEN-2a; MEN-2a syndrome; MEN Type IIa; Multiple endocrine adenomatosis type IIa; sickle syndrome
HistoryThis section has been translated automatically.
Sipple, 1961
DefinitionThis section has been translated automatically.
Disease belonging to the multiple endocrine neoplasms (OMIM 171400) with a combination of pheochromocytoma (possibly bilateral), medullary thyroid carcinoma, and possibly parathyroid adenoma, cutaneous lichen amyloidosus and Hirschprung's disease associated.
EtiopathogenesisThis section has been translated automatically.
Autosomal-dominantly inherited; mutation of the RET prooncogene, a gene coding for a transmembrane tyrosine kinase, which is mapped on chromosome 10q11.2
LiteratureThis section has been translated automatically.
Breza J Jr et al (2018) Multiple endocrine neoplasia 2A (MEN 2A) syndrome. Bratisl Lek Listy119:120-125.
Mathiesen JS et al (2022) Multiple endocrine neoplasia type 2: A review. Semin Cancer Biol 79:163-179
- Sipple JH (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31: 163-166
- Verga U et al (2003) Frequent association between MEN 2A and cutaneous lichen amyloidosis. Clin Endocrinol (Oxf) 59: 156-161.
Recommended articles
Incoming links (6)
Familial cancer syndrome; Lichen amyloidosis; Men type iia; Multiple endocrine adenomatosis type iia; Multiple endocrine neoplasias; Ret oncogene;Outgoing links (4)
Lichen amyloidosis; Multiple endocrine neoplasias; Pheochromocytoma; Ret oncogene;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer