DefinitionThis section has been translated automatically.
Harmless, in Asians frequent, in Caucasians rare, congenital, mostly extensive, in the sacral region localized, symptomless, dermal melanocytosis with gray-blue discoloration of the skin which in the majority of the affected persons regresses in the course of life.
S.a. further congenítal melanocytoses like:
Occurrence/EpidemiologyThis section has been translated automatically.
- Especially for Asians (70-90% for Mongolians, Japanese and Chinese)
- about 90% with Bolivian Indians
- also common among black Africans
- less frequently among members of the Caucasian race (1.0-2.0%).
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ManifestationThis section has been translated automatically.
- Congenital, more rarely occurring only in the first weeks of life;
- m>w
LocalizationThis section has been translated automatically.
Distal back region, above the sacrum, buttocks and lumbar region. 5% of Mongolian spots can be found on the lower extremity.
Clinical featuresThis section has been translated automatically.
Not always visible at first sight, grey or blue-grey, 5.0-10.0 cm in size, moderately sharp or even only running out, indistinctly limited, completely non-irritating stain (no subjective symptoms) with an unchanged surface (no hypertrichosis), which recedes in the first years of life.
HistologyThis section has been translated automatically.
TherapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
In larger collectives (n=2,100 infants) after one year, 15% of those affected showed a clear fading; 45% had completely disappeared. Lifelong persistence possible (evidence in about 4% of Japanese men between 18 and 22 years). Malignant degeneration was not observed.
Note(s)This section has been translated automatically.
In rare cases extensive mongol spots have been described in association with congenital storage diseases: mucopolysaccharidosis type I (Hurler syndrome), GM1-gangliosidosis type I, mucopolysaccharidosis type II (Hunter syndrome), mucolipidosis, mannosidosis, Niemann-Pick disease.
LiteratureThis section has been translated automatically.
- Gupta D et al (2013) Mongolian spots. Indian J Dermatol Venereol Leprol 79:469-478
- Reza AM et al (2010) Incidence of Mongolian spots and its common sites at two university hospitals in Tehran, Iran. Pediatrist Dermatol 27:397-398
- Ricci F (2016) Extensive, irregular Mongolian patches indicating GM1 gangliosidosis type I. JDDG 14: 301-302
- Shih IH et al (2007) A birthmark survey in 500 newborns: clinical observation in two northern Taiwan medical center nurseries. Chang Gung Med J 30:220-225
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Incoming links (13)
Atrophodermia idiopathica et progressiva; Caesiomarble phacomatosis; Deltoideoacromial nevus; Hunter's disease; Hyperpigmentation, circumscribed; IDS gene; Naevus; Nevus of Ota; Nevus yamamoto; Newborns, skin changes; ... Show allOutgoing links (4)
Deltoideoacromial nevus; Mucopolysaccharidoses hereditary (overview); Nevus of Ota; Nevus yamamoto;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
