Milia multiple eruptive L72.8

Polyätiological clinical picture characterized by the eruptive occurrence of 0.1-0.3 cm large, white, follicular horny beads (milia).

• Eruptive milia as side effects of therapy with tyrosine kinase inhibitors: The skin changes usually occur 2-20 days after the start of therapy. These include dryness, itching, burning and possibly pain in the first 2 weeks, increased sensitivity to light, keratitis (inflammation of the cornea), fatigue syndrome, maculopapular or pustular rosacea-like exanthema (see Acne medicamentosa) and milia. The milia, which are mainly located in the face, can occur as the sole symptom without further acne-like changes.
• Eruptive milia of unknown aetiology: These can occur at any age without a traceable cause (localization: face, neck, ears, trunk)
• Eruptive milia as follicular hamartomas: These are multiple follicular hamartomas that appear in different phases of life. Such hemartomas can be localized (follicular epidermal nevus), plaque-like or linear or disseminated as a partial symptom of complex malformation syndromes (e.g. Brooke-Spiegler syndrome or trisomy 13).

• Eruptive milia can be seen at any age as side effects of a therapy
• Eruptive milia of the adolescents are mainly centrofacial and in the forehead area.
• A rare form of eruptive milia is observed in middle adulthood (autosomal dominant inheritance?). Preferably located in the face and upper trunk.

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Corresponding milia by incision of the covering epidermis and expression of the small horny cyst. Abrasive measures can be helpful before.

1. Diba VC et al (2008) Multiple eruptive milia in a 9-year-old boy. Pediatrist Dermatol 25:474-476
2. Gonul M et al (2015) Multiple eruptive milia on scalp. J Eur Acad Dermatol Venereol doi: 10.1111/jdv.13476
3. Heard MG et al (1971) The familial occurrence of multiple eruptive milia. Birth Defects Orig Artic Ser 7:333-337
4. Jung SW et al (2015) Multiple eruptive milia and milia en plaque on the hands and feet of a 2-month-old female. J Dermatol 42: 931-93
5. Kurashige Y et al (2013) Spontaneous multiple eruptive milia in a 91-year-old man. J Dermatol 40: 290-291
6. Langley RG et al (1997) Multiple eruptive milia: report of a case, review of the literature, and a classification. J Am Acad Dermatol 37: 353-356
7. Miescher G (1957) Eruptive milia and Brooke's epithelioma adenoides cysticum. Dermatologica 115:712-716
8. Sharma R et al (2011) Multiple eruptive milia over both external ears. Indian J Dermatol Venereol Leprol 77:519-520
9. Sambrano BL et al (2013) Eruptive milia secondary to vemurafenib. J Am Acad Dermatol 69:e258-60
10. Tharini G et al (2012) Congenital hypotrichosis, eruptive milia, and palmoplantar pits: a case report with review of literature. Int J Trichology 4:32-35