DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
2,3–8,3 h
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Pharmacodynamics (Effect)This section has been translated automatically.
Excitation of muscarinic choline receptors by release of acetylcholine; dopamine antagonist.
IndicationThis section has been translated automatically.
Nausea, vomiting, prophylaxis of cytostatic-induced nausea.
Limited indicationThis section has been translated automatically.
Pregnancy (1st trimenon), lactation, depression, children < 14 years, breast cancer in the history, renal insufficiency.
Dosage and method of useThis section has been translated automatically.
2 mg/kg bw i.v. as a short infusion 30 minutes before administration of the cytostatic drug and 1.5/3.5/5.5 and 8.5 hours after administration of the cytostatic drug. Alternatively, 0.5-1 mg/kg bw/hour i.v. starting 2 hours before administration of cytostatics over 24 hours as continuous infusion.
Undesirable effectsThis section has been translated automatically.
Malignant neuroleptic syndrome (extrapyramidal symptoms, subfebrile temperatures, polypnoea, tachycardia, salivation, sweating, loss of consciousness), CNS disorders, galactorrhea, gynecomastia, hyperprolactinemia, menstrual disorders.
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Prolactinoma, intestinal obstruction, epilepsy, extrapyramidal symptoms, children < 2 years, gastrointestinal bleeding, MAO-inhibitor intake, pheochromocytoma.
PreparationsThis section has been translated automatically.
Gastrosil; Paspertine; MCP
TablesThis section has been translated automatically.
Essential interactions of metoclopramide
Alimemazine |
extrapyramidal symptoms ↑ |
Anticholinergics |
mutual effect ↓ |
Antidepressants, tricyclic |
extrapyramidal symptoms ↑, fatigue ↑ |
Atovaquon |
Atovaquone effect ↓ |
Barbiturates |
Tiredness ↑ |
Ciclosporin A |
Ciclosporin levels ↑ |
Cimetidine |
Cimetidine level ↓, intake 2 hours apart |
Digoxin |
Digoxin level ↓ |
Ipatropium bromide |
mutual effect ↓ |
Lisurid |
Lisuride effect ↓ |
Neuroleptics |
extrapyramidal symptoms ↑ |
Sleeping pills |
Tiredness ↑ |
Scopolamine |
mutual effect ↓ |
Sympathomimetics |
Avoid combination |
Tranquillizer |
extrapyramidal symptoms ↑, fatigue ↑ |
Prof. Dr. med. Peter Altmeyer