Mesna

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Mucolytic, mucosal protector.

Half-life
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1,5 h

Indication
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Prophylaxis of the urotoxicity of oxazaphosphorins (e.g. cyclophosphamide).

Limited indication
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patients with autoimmune diseases (increased risk of allergic reactions).

Dosage and method of use
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Inject 20% of the oxazaphosphorin dose at time 0 (= injection of the cytostatic drug), 4 and 8 hours i.v.

Undesirable effects
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Allergic reactions, temporary increases in transaminases, vein irritation at the injection site, gastrointestinal disturbances, drop in blood pressure, tachycardia.

Contraindication
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Pregnancy, lactation, hypersensitivity to thiol compounds.

Preparations
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Uromitexane

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Last updated on: 29.10.2020