Mepivacaine

Mepivacaine is a local anaesthetic of the amide type (prototype is lidocaine) with the molecular formula: C15H22N2O. Mepivacaine is mainly used for infiltration and conduction anaesthesia.

Mepivacaine, like all Na+ blockers, leads to a blockade of the voltage-dependent Na channels. The influx of sodium into the nerve fibre is inhibited, the formation of an action potential is prevented.

Mepivacaine hydrochloride is a racemate of the (R)-form and (S)-form. In the field of block anaesthesia it is often used for peripheral nerve blocks. Mepivacaine has a rapid onset of action due to good diffusion in tissue and a duration of action between 1.5 and 3 hours.

0,5-4 % (maximum 3 mg/kg bw).

Depending on the plasma level, neurological and cardiac symptoms (e.g. cardiac arrhythmia) may occur (e.g. under local anaesthetics)

Meaverin®, Scandicain®