Synonym(s)
HistoryThis section has been translated automatically.
Ramamurthy 1976
DefinitionThis section has been translated automatically.
Rare infant dermatosis that is already manifest at birth. The (post-inflammatory) brown spots that gave the disease its name persist for a few months, the vesicles and pustules for a few days.
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Occurrence/EpidemiologyThis section has been translated automatically.
Prevalence of 4-5% in African American newborns. In Caucasian newborns the prevalence is significantly lower at 0.1-0.6% (Reginatto FP et al. 2017).
EtiopathogenesisThis section has been translated automatically.
ManifestationThis section has been translated automatically.
Already present at birth, increased occurrence in African-American infants.
LocalizationThis section has been translated automatically.
neck, face, trunk, palmo-plantar
Clinical featuresThis section has been translated automatically.
No general symptoms. Disseminated brown spots with non follicular vesicles and pustules scattered throughout the body. Typical infestation of Palmae and Plantae. In addition to 0.1-0.2 cm large flaccid vesicles and flaccid pustules, older lesions show brown spots with or without Collerette-like dry scaling.
In dark-skinned newborns the lesions often heal hyperpigmented. In light-skinned babies the post-inflammatory dark spotting is usually absent. The hyperpigmentations are reversible and disappear completely after 2-3 months.
HistologyThis section has been translated automatically.
DiagnosisThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
Erythema (toxicum) neonatorum: Occurs only 12-48 hours after birth; lasts 3-4 days; exanthema emphasizing the extremities; no infestation of Palmae and Plantae.
Pyoderma: localized infestation; no exanthema or generalized picture; pathogen detection.
Infantscabies: not present at birth; usually localized infestation; medical history; mites.
Acropustulosis, infantile: clinically and histologically large analogies; in infantile acropustulosis the hyperpigmentations are missing.
TherapyThis section has been translated automatically.
Not required. Drying out if necessary, e.g. lotio alba.
Progression/forecastThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Barr RJ et al (1979) Transident neonatal pustular melanosis. Int J Dermatol 18: 636-683
- Ghosh S (2015) Neonatal pustular dermatosis: an overview. Indian J Dermato 60: 211
- Hansen LP et al (1985) Erythema toxicum neonatorum with pustulation versus transitory neonatal pustular melanosis. dermatologist 36: 475-477
- Mebazaa A et al (2011) Transient pustular eruption in neonates. Arch Pediatr 18: 291-293
- Mengesha YM et al (2002) Pustular skin disorders: diagnosis and treatment. At J Clin Dermatol 3: 389-400
- Ramamurthy RS, Reveri M, Esterly NB, Fretzin DF, Pildes RS (1976) Transient neonatal pustular melanosis. J Pediatr 88: 831-835
Reginatto FP et al.(2017)Epidemiology and Predisposing Factors for Erythema Toxicum Neonatorum and Transient Neonatal Pustular: A Multicenter Study.Pediatric Dermatol 34:422-426.
- by Delft R et al.(2012) A neonate with vesicopustular rash. Ned Tijdschr Geneeskd 156:A 2816
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Incoming links (6)
Acropustulosis of infancy; Eosinophilic pustular folliculitis; Erythema neonatorum; Newborns, skin changes; Transient neonatal pustular melanosis; Transitory neonatal pustular melanosis;Outgoing links (7)
Acropustulosis of infancy; Bubbles; Dermis; Erythema neonatorum; Pustule; Pyoderma; Skabies;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
