Megluminantimonate

Like the competing product sodium stibogluconate, meglumine antimonate is a pentavalent antimony compound. Both substances are included in the WHO list of essential medicines. Meglumine antimonate has a molecular weight of 365.98.

Leishmaniasis.

Remember! Maximum dose 850 mg/day!

• Visceral Leishmaniasis: 20 mg/kg bw/day for at least 20 days (until no more parasites can be detected).
• Cutaneous leishmaniasis (except L. aethiopica, brasiliensis, guyanamensis):
  • Local therapy: Injection of 1-3 ml under the ulcer, possibly 1-2 scds at intervals of 1-2 days.
  • Systemic: 10-20 mg/kg bw/day until the smears are negative and then another 3 days.
• Cutaneous leishmaniasis (L. brasiliensis): 20 mg/kg bw/day until the lesion is healed (max. 4 weeks).
• Mucocutaneous leishmaniasis: 20 mg/kg bw/day until the smear is negative (max. 4 weeks).
• Diffuse cutaneous leishmaniasis: 20 mg/kg bw/day until clinical improvement occurs (usually for months).

1. Fernandez-Flores A et al. (2015) Morphological and immunohistochemical clues for the diagnosis of cutaneous leishmaniasis and the interpretation of CD1a status. J Am Acad Dermatol doi: 10.1016/j.jaad.2015.09.038
2. Fischer T et al. (2024)Treatment of mucocutaneous leishmaniasis- a systematic review. JDDG 22:763-774
3. Handler MZ et al. (2015) Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management.J Am Acad Dermatol 73: 911-26; 927-8.