The vacuolated degeneration of the basal epithelial cell layers can occasionally lead to larger slit-like clefts known as Max-Joseph's spaces. In extreme cases, these clefts lead to the formation of subepithelial blisters (lichen planus vesiculosus or bullosus).
Max Joseph spaces
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- Ross TH (1977) Caspary-Joseph spaces: a comment on priority. Int J Dermatol 16:842-843.