Marburg virus diseaseB34.8

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Marburg Hemorrhagic fever

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HistoryThis section has been translated automatically.

Martini et al., 1968

DefinitionThis section has been translated automatically.

Zoonosis with highly contagious haemorrhagic fever, endemic in monkeys (Uganda) Secondary infections from person to person are possible.

PathogenThis section has been translated automatically.

Marburg virus (filoviruses); the virus genome consists of unsegemented, linear, single-stranded RNA. Marburg virus and Ebola virus form the family Filoviridae. S.a. Haemorrhagic fever syndromes.

EtiopathogenesisThis section has been translated automatically.

Infection with Marburg viruses after contact with infected monkeys or their tissues (first description 1967: laboratory infection by monkeys imported from Africa (green monkeys), parallel in Marburg and Belgrade). After infection of a human secondary transmission from human to human is possible, especially after contact with blood, secretion or tissue.

Clinical featuresThis section has been translated automatically.

After an incubation period of 3-16 days development of severe hemorrhagic fever. Acute, highly febrile beginning with headache, photophobia, myalgia, vomiting and diarrhoea. Maculo-papular, purple exanthema, deep red enanthema. Bleeding in the skin and mucous membranes are harbingers of the lethal outcome.

TherapyThis section has been translated automatically.

Symptomatic. Obligation to report and isolate the patient on suspicion.

Progression/forecastThis section has been translated automatically.

Lethalities 25-50%.

Note(s)This section has been translated automatically.

Duty to report suspicion, illness and death.

LiteratureThis section has been translated automatically.

  1. Hart MK (2003) Vaccine research efforts for filoviruses. Int J Parasitol 33: 583-595
  2. Hofmann H et al. (1969) Ecology of "marburgvirus" (Rhabdovirus simiae) Central Bacteriol 212: 168-173
  3. Martini GA, Knauff, HG, Schmidt HA et al. (1968) On a previously unknown infectious disease introduced by monkeys: Marburg Virus Disease. Dtsch med Wschr 53: 559

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer