DefinitionThis section has been translated automatically.
Very rare, undifferentiated, malignant adnexal tumor developing at the base of a spiradenoma.
LocalizationThis section has been translated automatically.
The head, neck, upper trunk area or bending sides of the arms are affected. Infestation of the vulva is described.
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Clinical featuresThis section has been translated automatically.
Mostly solitary, suddenly growing node, which has grown on the ground of a pre-existent spiradenoma. The clinical picture is not very characteristic apart from the possible painfulness. The diagnosis is generally a histological accidental finding.
HistologyThis section has been translated automatically.
In most cases the very distinct histological morphology of the spiradenoma is still detectable with a deeply dermal nodular tumor complex, partly consisting of one or more nodes. Parenchyma consisting of basaloid, poorly differentiated polymorphic cell complexes. Partially also spindle cell differentiation. Numerous mitoses, mass necroses. Often clear lymphocytic infiltrate.
Complication(s)This section has been translated automatically.
Metastasis in 20% of cases.
TherapyThis section has been translated automatically.
Excision according to the criteria of the spinocellular carcinoma, necessarily with marginal incision controls and lymph node mapping ( sentinel lymph node dissection).
Note(s)This section has been translated automatically.
Spiradenocarcinoma is "frequently" associated with cylindromes.
LiteratureThis section has been translated automatically.
- Catteau X et al. (2020) Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV. Diagn Pathol 15: 24.
- Granter SR et al (2000) Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. Am J Dermatopathol 22: 97-103.
- Leonard N et al (2003) Low-grade malignant eccrine spiradenoma with systemic metastases. Am J Dermatopathol 25: 253-255.
- Mirza I et al (2002) Malignant eccrine spiradenoma. Arch Pathol Lab Med 126: 591-594.
- Rutten A (2002) Eccrine sweat gland carcinoma of the skin. Pathologist 23: 79-88
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Outgoing links (4)
Excision; Sentinel lymph node dissection; Spiradenoma; Squamous cell carcinoma of the skin;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer