Lymphocytic infiltration of the skin L98.8

clinical picture, the entity of which is increasingly disputed. The term, introduced at a meeting of the Bronx Dermatological Society some 50 years ago, was purely descriptive and did not claim to be an independent disease. Nevertheless, it subsequently spread in dermatological textbooks under the term "lymphocytic infiltration". Many authors assume that the term can be deleted without replacement; the diagnosed cases are probably cases of lupus erythematosus tumidus, lymphadenosis cutis benigna, polymorphic light dermatosis or lymphoma-like insect bite reactions.

Unclear, entity disputed. There have been reports of drug or infectious (Borrelia, Leishmania) induction of symptoms (ACE inhibitors). Some authors classify these skin symptoms as a variant of lupuserythematosus (lupus erythematosus tumidus).

No gender preference; adults under 50 years of age; familial occurrence has been reported several times.

Mainly face: Forehead, cheeks; also neck and nape of neck.

Solitary or multiple, symmetrically or asymmetrically localized, asymptomatic (symptoms vary and range from asymptomatic to itching and burning - Sánchez CE et al. 2023), differently sized, usually sharply defined, reddish or brownish-red, also brown, plaque- or cushion-like raised, firm, roundish, oval or even polygonal lesions. No scaling or crusting. No ulceration of the surface. Healing without scars after weeks or months.

S.u. differential diagnosis and the respective clinical pictures.

The following disease patterns are not "true differential diagnoses", but rather reliable final diagnoses that could be determined after the primary clinical diagnosis "lymphocytic infiltration of the skin".

• Lymphadenosis cutis benigna
• lupus erythematosus tumidus
• Lupus erythematosus hypertrophicus et profundus
• Lupus erythematodes chronicus discoides
• polymorphic light dermatosis
• Dermatosis, acute febrile neutrophils.

1. Bahmer FA (1992) Therapy for lymphocytic infiltration. Dermatologist 43: 663
2. Morgan J et al. (1990) Satisfactory resolution of Jessner's lymphocytic infiltration of the skin following treatment with etretinate. Br J Dermatol 122: 570
3. Dippel E et al. (2002) Familial lymphocytic infiltration of the skin: histochemical and molecular analysis in three brothers. Dermatology 204: 12-16
4. Jessner M, Kanof NB (1953) Lymphocytic infiltration of the skin. 68: 447-449 Arch Dermatol 68: 447-449
5. Sánchez CE et al. (2023) Jessner's Lymphocytic Infiltration of the Skin in a 73-Year-Old Woman: A Case Report. Am J Case Rep 24:e938969
6. Schepis C et al. (2004) ACE-inhibitor-induced drug eruption resembling lymphocytic infiltration (of Jessner-Kanof) and lupus erythematosus tumidus. Dermatology 208: 354-355
7. Steinmann A et al. (1999) Palpable migratory acriform erythema and lymphocytic infiltration of the skin--different presentations of the same entity? Dermatology 50: 270-274
8. Toonstra J et al. (1989) Jessner's lymphocytic infiltration of the skin. Arch dermatol 125: 1525-1530
9. Weyers W et al. (1998) LE or not LE- that is the question: An unusual attempt to separate lymphocytic infiltration from the spectrum of discoid lupus erythematosus. Am J Dermatopathol 20: 225-232
10. Ziemer M et al. (2009) Lymphocytic infiltration of the skin (Jessner-Kanof) but not reticular erythematous mucinosis occasionally represents clinical manifestations of Borrelia-associated pseudolymphoma. Br J Dermatol 161:583-590