Synonym(s)
DefinitionThis section has been translated automatically.
Very differently used and therefore not clearly defined term for a localized or generalized, congenital or acquired, partial or complete loss of (subcutaneous) fatty tissue.
The term lipodystrophy is often used synonymously with lipoatrophy.
However, lipodystrophy includes lipatrophy.
Lipodystrophy can be accompanied by a simultaneous redistribution of fatty tissue (e.g. HIV-induced lipodystrophy).
ClassificationThis section has been translated automatically.
A classification of lipodystrophies according to their mode of origin (acquired or congenital/familial), their pattern of affection (localized, partial, or generalized), and the presence of endocrinologic (diabetes mellitus) and other internal disorders (hepatomegaly, glomerulonephritis, hypertriglyceridemia) is accepted.
- Congenital/familial:
- Generalized:
- Lipodystrophy, generalized (congenital generalized lipatrophy).
- Partial:
-
Familial partial lipodystrophy syndromes:
- Koebberling-Dunningham type (type 1)
- Dunningham type (type 2)
- Barrosa type (type 3)
- Lipodystrophy with mandibuloacral dysplasia
SHORT syndrome (mutation in PIK3R1 gene/171833/ on chromosome 5q13)
-
Familial partial lipodystrophy syndromes:
- Generalized:
- Acquired:
- Generalized:
- Partial:
- Lipodystrophycaused by protease inhibitors (HIV)
- Lipodystrophy, progressive partial (Barraquer-Simons).
- Localized:
- Traumatic (e.g., after wearing lacing garments (e.g., bra straps, rings, belts).
- Lipoatrophy semicircularis (anularis)
- Lipoatrophy after injections (glucocorticoids, insulin, growth hormone)
- Lipodystrophy after panniculitis
- Lipodystrophy after/in collagenoses(morphea, lupus erythematosus profundus).
- Unexplained:
- Lipodystrophia centrifugalis abdominalis infantilis
- Panatrophia localisata (Gowers)
- Hemiatrophia faciei progressiva (Parry Romberg)
- Non-progressive late onset hemifacial lipoatrophy.
LiteratureThis section has been translated automatically.
- Akdeniz S et al (2000) Partial lipodystrophy with hemithoracic atrophy. Br J Dermatol 143: 665-666
- Behrens GM et al (2003) Clinical impact of HIV-related lipodystrophy and metabolic abnormalities on cardiovascular disease. AIDS 17: S149-154
- Buyukgebiz A et al (1999) Localized lipatrophia due to recombinant growth hormone therapy in a child with 6.7 kilo base gene deletion isolated growth hormone deficiency. J Pediatr Endocrinol Metabol 12: 85-87
- Carr A (2003) HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management. AIDS 17: 141-148
- Carr A et al (2003) An objective case definition of lipodystrophy in HIV-infected adults: a case-control study. Lancet 361: 726-735
- Hartmann M et al (2000) Lipodystrophy syndrome in HIV infection. dermatologist 51: 159-163
- Helmet TN et al (2001) Lipodystrophy. Cutis 67: 163-164
- Joffe BI et al (2001) From lipodystrophy syndromes to diabetes mellitus. Lancet 357: 1379-1381
- Martinez E et al (2003) Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection. N Engl J Med 349: 1036-1046
- Sattler F (2003) Body habitus changes related to lipodystrophy. Clin Infect Dis 36: S84-S90
Incoming links (7)
Gluten-Related Dermatological Disorders; Haart; Lawrence syndrome; Lipatrophy; Lipoatrophy; Membranoproliferative glomerulonephritis; Primary immunodeficiencies and skin;Outgoing links (15)
Circumscribed scleroderma; Familial partial lipodystrophies; Lawrence syndrome; Lipoatrophy, localized after glucocorticosteroid injections; Lipodystrophia centrifugalis abdominalis infantilis; Lipodystrophia generalisata acquisita; Lipodystrophy familial type barroso; Lipodystrophy generalized; Lipodystrophy progressive partial; Lipodystrophy with mandibulo-acral dysplasia; ... Show allDisclaimer
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