DefinitionThis section has been translated automatically.
antibiotics produced by Streptomyces species. There is a relationship to the macrolide antibiotics with regard to spectrum of action and mechanism of action. The only representative of lincosamides is clindamycin, a semi-synthetic analogue of lincomycin. Clindamycin is a weak base that is attached to the 50S subunit of bacterial ribosomes and inhibits protein synthesis.
Remark: Lincomycin is no longer used by hete.
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of protein synthesis at the 50S subunit of the bacterial ribosome.
Note(s)This section has been translated automatically.
Clindamycin is the most effective antibiotic against anaerobes. It is also excellent against staphylococci and good against streptococci and pneumococci.
LiteratureThis section has been translated automatically.
Graefe KH et al (2016) Antibacterial agents. In: Graefe KH et al (Eds) Pharmacology and Toxicology. Georg Thieme Publisher Stuttgart S. 583-584
Prof. Dr. med. Peter Altmeyer