Lgg

Author: Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2021

Synonym(s)

Lactobacillus Goldin and Gorbach; Lactobacillus rhamnosus GG

Definition
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Lactobacillus Goldin and Gorbach, physiologically occurring germs in the intestinal flora. Protective germs reduced by the use of antibiotics, but also by modern food. s.a. Probiotics

Pharmacodynamics (Effect)
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Recolonization of the intestinal flora, normalizing effect on the immune system. While an early Finnish study indicated a 68% reduction in the rate of manifestation of atopic eczema in children with a family history of the disease, more recent studies indicated a 21% reduction, although the identical bacterial strains were not always used.

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Dermatology

Eczema, atopic. chronic, recurrent, itchy red spots and slightly raised red plaques on the cheeks...

Atopic dermatitis (overview)

A multifactorial, chronically persistent or chronically recurrent, non-contagious, usually very itchy derma...

Indication
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Normalization of the intestinal flora, e.g. after antibiotic therapy, controversially discussed as prophylaxis of atopic eczema in high-risk children, i.e. children who have atopic predisposed parents.

Pregnancy/nursing period
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Is administered especially in the last two months of pregnancy in case of atopic predisposition.

Complication(s)
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Contains milk protein, caution in case of a high-grade milk protein allergy!

Dosage and method of use
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LGG® Lactobacillus rhamnosus GG Capsules: 2 x daily 1 capsule together with 1 glass of water with meals.

For infants, open the capsule and stir the contents into cool to lukewarm water.

Do not add to fruit juices, tea, hot food or drinks above 37°C.

Dosage as a prophylactic (now controversial): Mother 2 months before delivery 2 Kps LGG /day. The infant receives 1 capsule (opened, sprinkled in food) up to 2 years.

Undesirable effects
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Occasionally, diarrhoea can occur at short notice, especially at the beginning of treatment.

Cave!

Milk protein allergy.

Contraindication
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Allergy to one of the ingredients

Note(s)
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Food supplement, not medicine.

Patientinformation
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LGG currently counts as a food supplement and is not available on prescription at the expense of the statutory health insurance.

Literature
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Kalliomaki M et al (2001) Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357: 1076-1079
Isolauri E (2000) Probiotics in the management of atopic eczema. Clin Exp Allergy 30: 1604-1610
Tang ML et al (2010) Probiotics and prebiotics: clinical eff ects in allergic disease. Curr Opin Pediatr 22: 626-3440
Pelucchi C et al (2012) Probiotics supplementation du-ring pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology 23: 402-1441
Schäfer T. (2014) S3 guideline allergy prevention - update 2014guideline of the German Society of Allergology and Clinical Immunology (DGAKI) and the German Society of Pediatrics and Adolescent Medicine (DGKJ) Allergo J Int 23: 32-46.
Krämer1 S. et al (2007) Application of Lactobacillus rhamnosus GG preparations for prevention of atopic diseases; Lactobacillus Rhamnosus GG Preparations for Prevention of Atopic DermatitisS. Current Nutritional Medicine 32: 80-81