Synonym(s)
hereditary subtotal leukonychia; hereditary white nails; Sub-totally hereditary leukonychia
DefinitionThis section has been translated automatically.
Very rare disease of the fingernails with distal white coloration of all fingernails.
EtiopathogenesisThis section has been translated automatically.
Autosomal dominant inheritance, partly with variable penetrance. A defect of keratin-coding genes on chromosome 12q13 is suspected, which leads to disturbed formation of keratinocytes with formation of intracellular vacuoles and a reduced compactness of the keratin.
Clinical featuresThis section has been translated automatically.
Distal white coloration of finger and/or toenails, usually combined with transparent yellow coloration proximally.
LiteratureThis section has been translated automatically.
- Ingegno AP et al (1982) Hereditary white nails (leukonychia totalis), duodenal ulcers, and gallstones. Genetic implications of a syndrome. N Y State J Med 82: 1797-1800
- Marcilly MC et al (2003) Sub-total hereditary leukonychia, histopathological and electron microscopy study of "milky" nails. Ann Dermatol Venereol 130:50-54
- Norgett EE et al (2004) Hereditary 'white nails': a genetic and structural study. Br J Dermatol 151: 65-72
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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer