DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
10–15 h
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Pharmacodynamics (Effect)This section has been translated automatically.
Nucleoside analogue, competitive inhibitor of the reverse transcriptase of HIV.
IndicationThis section has been translated automatically.
Combination therapy of HIV infection, usually with a PI or NNRTI. Compensated chronic hepatitis B (in adults), decompensated hepatitis B (in adults).
Dosage and method of useThis section has been translated automatically.
- HIV infection (Epivir): Pat. > 12 LJ: 2 times/day 150 mg p.o. or 1 time/day 300 mg p.o.
- Pat. > 3 months - 12 LJ: 2 times/day 4 mg/kg bw (max. 300 mg/day).
- Hepatitis (Zeffix): 100 mg/day p.o.
Remember! Dose adjustment necessary in case of reduced creatinine clearance.
Undesirable effectsThis section has been translated automatically.
Allergic exanthema, nausea, insomnia, headache, fever, fatigue, diarrhea, abdominal pain, neutropenia, anemia.
InteractionsThis section has been translated automatically.
Cotrimoxazole leads to an increase in lamivudine levels.
ContraindicationThis section has been translated automatically.
Children with a history of pancreatitis, lactation.
PreparationsThis section has been translated automatically.
Epivir, Zeffix
Prof. Dr. med. Peter Altmeyer