Lactoferrin

Iron binding protein structurally and functionally related to transferrin, which is synthesized in neutrophil granulocytes and glandular epithelial cells. Lactoferrin is detectable in very small amounts in serum.

Like transferrin, lactoferrin binds 2 atoms of iron per molecule. It plays a role in granulocytopoiesis, in the formation of hydroxy radicals in neutrophil granulocytes and has a bacteriostatic and bactericidal protective effect. Congenital lactoferrin deficiency is associated with recurrent infections.

In a double-blind, placebo-controlled study (n=82), daily intake of lactoferrin in combination with vitamin E and zinc was shown to be successful in mild to moderate acne vulgaris.

1. Chan H et al (2017) A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol 56:686-690.
2. Legrand D (2012) Lactoferrin, a key molecule in immune and inflammatory processes. Biochem Cell Biol 90:252-268.
3. Foreland LH (1999) Lactoferrin: a multifunctional glycoprotein. APMIS 107: 971-981.