DefinitionThis section has been translated automatically.
KRT6C (Keratin 6C) is a protein-coding gene located on chromosome 12q13.13. An important paralog of this gene is KRT6B and KRTB9.
General informationThis section has been translated automatically.
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. Type II keratins are clustered in a region of chromosome 12q13.
Diseases associated with KRT6C include:
- epidermolytic palmoplantar keratosis (keratoderma) (EPPK)
- Palmoplantar keratosis, non-epidermolytic, focal or diffuse
- Pachyonychia congenita
LiteratureThis section has been translated automatically.
- Li P et al. (2023) Proteomic profiling reveals KRT6C as a probable hereterodimer partner for KRT9: New insights into re-classifying epidermolytic palmoplantar keratoderma (EPPK) and a milder form of pachyonychia congenita (PC-K6c) as a group of genetic cutaneous disorders. J Proteomics 287:104971.
