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Comedones and cysts in severe acne comedonica: numerous single (horizontal arrows) and double comedones (vertical arrows). circles: cysts.



Formation of comedones in massive actinic elastosis.

Comedo: multiple, differently sized, closed comedones (whiteheads, which are easily recognizable under lateral illumination. few inflammatory papules.

Comedo: multiple, chronically stationary, 0.5-1 mm large, firm, asymptomatic, grey, rough follicular papules with enlarged follicles, localized in the nasolabial fold; sebaceous content can be expressed on pressure.

Comedones: encircled a group of shotgun-like comedones of different sizes; arrow horizontal points to a capillary hemangioma, arrow vertical to a sebaceous gland hyperplasia (characteristic of the surface gloss with a central porus (magnification) and the broad-based attachment).

Comedones in dark skin.

Comedo:multiple, chronically stationary, 0.5-1 mm large, firm, asymptomatic, grey, rough follicular papules with enlarged follicles, localized in the nasolabial fold; sebaceous content can be expressed on pressure.

Comedones: numerous black (irritationless) comedones standing in groups with known now largely healed acne conglobata.

Comedo: funnel-shaped scars as well as comedones in case of known (in the meantime largely subsided) acne vulgaris.

Comedo: approx.0.4 cm large, flat raised, firm papule with an approx. 0.1 cm large, black, keratotic centre (black head).

Comedo (giant comedo): approx. 2.0 cm large, firm knot with a black, keratotic centre about 0.3 cm in size.

Comedo(reflected light microscopy): Blackhead comedo on the back; black horn plug surrounded by a blue-black wall (horn material translucent from depth).

Comedone-like keratosis follicularis (see there): in contrast to classical comedones, keratosis follicularis lacks sebaceous gland hyperplasia ; keratosis follicularis is a follicular, "dry horn graft" which does not occur in the seborrhoeic zones but mainly on the side of the extremities.

Comedo: dilated, sinusoidal twisted infundibulum with irregularly thick, ortho- or parakeratotic cornified squamous epithelium. In the center of the comedo loosely layered, ortho- or parakeratotic corneal masses, interspersed with numerous bacterial turf and pityrosporon spores (not clearly identifiable in the overview). Lower left atrophic hair follicle. Clear dermal fibrosis.


Comedo: congested hair follicle, laser scanning microscopy, intraepidermal

Comedo: Identical hair follicle in the corium, perforating there, laser scanning microscopy, - see red marking