DefinitionThis section has been translated automatically.
Mice (experimental animals) in which certain genes have been specifically switched off using molecular biological methods.
General informationThis section has been translated automatically.
Molecular genetic manipulations are performed on embryonic stem cells (of mice), which are then introduced into the germ line of a mouse. Knockout mice are now available for a wide range of research areas. With the help of the genetically modified animals, biological mechanisms can be investigated ( angiogenesis). They are also suitable as models for human diseases or for pharmacological questions (research into the pathogenesis and therapy of many skin diseases, e.g. psoriasis).
LiteratureThis section has been translated automatically.
- Elmets CA (2006) An animal model of psoriasis in mice deficient in epidermal Jun proteins. Arch Dermatol 142: 1499-1500
- Lin EY et al (2006) Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res 66: 11238-11246
Prof. Dr. med. Peter Altmeyer