KinD48.9

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Acronym for "keratinocytic intraepithelial neoplasia" analogous to the acronyms: CIN, AIN, PIN.

ClassificationThis section has been translated automatically.

  • Clinically, the following distinct clinical pictures are subsumed under KIN:
  • Histologically, a distinction is made depending on the occurrence and density of the atypical keratinocytes:
    • KIN I: Lower third of the epithelium (early in situ SCC - KIN I or AKI)
    • KIN II: Lower two thirds of the epithelium (early in situ SCC - KIN II or AKI)
    • KIN III: Complete infestation of the epithelium; (Carcinoma in situ . KINIII or AK III)

HistologyThis section has been translated automatically.

Loss of normal skin stratification. Often nuclear polymorphisms, hyperchromasia, development of coliocytosis. Bulky superficial round cell infiltrates, basement membrane intact. In the lichenoid type of AK an interface dermatitis is found which reminds of a lichen planus. Tab.

TablesThis section has been translated automatically.

Stadium

Dysplasia/Grading

Histological description

KIN I

mild dysplasia

Small cellular atypias, often koilocytes with enlarged irregular nuclei and halo.

CHIN II

Moderate dysplasia

Replacement of up to 50% of the epithelium by atypical keratinocytes with increased nuclear plasma ratio.

KIN III

Severe dysplasia/carcinoma in situ

Replacement of > 50% of the surface epithelium including adnexal structures by atypical, partly also binuclear keratinocytes; increased number of mitoses.

Note(s)This section has been translated automatically.

Classification not yet generally usual. S.u. Keratosis actinica.

LiteratureThis section has been translated automatically.

  1. Cockerell CJ (2000) Histopathology of incipient intraepidermal squamous cell carcinoma ("actinic keratosis"). J Am Acad Dermatol 42: 11-17
  2. Fu W, Cockerell CJ (2003) The actinic (solar) keratosis: a 21st-century perspective. Arch Dermatol 139: 66-70
  3. Yantsos VA et al (1999) Incipient intraepidermal cutaneous squamous cell carcinoma: a proposal for reclassifying and grading solar (actinic) keratoses. Semin Cutan Med Surg 18: 3-14

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer