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Keratosis palmoplantaris with spiky keratoses
Synonym(s)
punctate keratoderma; Spike-like keratosis palmo-plantaris; Spiny Hyperkeratosis palmaris et plantaris; Spiny keratoderma of the palms and soles
DefinitionThis section has been translated automatically.
Rare palmoplantar keratosis of the palms of the hands and soles of the feet characterized by multiple, symptomless, skin-colored, spike-like, spiky hyperkeratoses about 0.1 cm in size.
Clinical featuresThis section has been translated automatically.
2 forms are distinguished:
- The hereditary, autosomal dominant form, which manifests itself between the age of 12 and 50. It can be accompanied by recurrent hypertension, left concentric heart hypertrophy. Accompanying hyperlipidemia has also been described.
- The acquired, late-manifested form, which occurs after the age of 50 and may be associated with malignancies. Renal, rectal, mammary and bronchial carcinomas have been described in association. Associations with type IV hyperlipoproteinemia, chronic renal insufficiency, myelofibrosis and polycystic kidneys are also suspected.
HistologyThis section has been translated automatically.
Compact hyperkeratosis, interspersed with vertically aligned parakeratosis cones.
TherapyThis section has been translated automatically.
A successful therapy does not exist. Symptomatic local therapy.
Note(s)This section has been translated automatically.
The dermatological indication of a possible systemic disease is decisive.
LiteratureThis section has been translated automatically.
- Baratli J et al (2012) Spiny hyperkeratosis palmaris et plantaris. Dermatologist 63: 923-926
- Chee SN et al (2017) Spiny keratoderma: case series and review. Int J Dermatol 56:915-919.