Keratoacanthoma centrifugum marginatum L23.9

Heid et al. 1979

Rare, clinical variant of giant keratoakanthoma with preferred centrifugal growth. Initially, Keratoacanthoma centrifugum marginatum develops from an inconspicuous reddish papule. In the initial growth phase, the typical morphological features and growth behaviour of the classical keratoacanthoma are evident (surprisingly rapid growth, central horn plug, marginal lip formation). Primary centrifugal growth results in reddish-brownish, solid, plate-like infiltrates of the skin with a nodular rim (Georgescu TA et al. 2017). In the central areas the tumour can heal completely. Complete spontaneous healing has been described (El-Khayat RH et al. 2014).

Unexplained; traumas? HPV infection (Yang Y et al. 2015)?

1. El-Khayat RH et al (2014) Spontaneous resolution of keratoacanthoma centrifugum marginatum. Clin Exp Dermatol 39:854-856.
2. Georgescu TA et al (2017) Keratoacanthoma centrifugum marginatum: an unusual clinical and histopathological diagnostic pitfall. Rome J Morphol Embryol 58:561-565.
3. Heid E et al (1979) Keratoacanthoma centrifugum marginatum. Ann Dermatol Venereol 106: 367-370.
4. Yang Y et al (2015) Two cases of giant keratoacanthoma centrifugum marginatum accompanied by α-human papillomavirus infection. Int J Dermatol 54:951-954.

5. Xiao H et al (2021) Keratoacanthoma centrifugum marginatum. Dermatol Online J 27:13030/qt5vp5f7bq.