KeratinamyloidosesE85.4

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Non-systemic, localized amyloidoses which occur exclusively in the skin and are characterized by deposition of amyloid (amylum = starch) of epidermal origin.

ClassificationThis section has been translated automatically.

A distinction is made between:

EtiopathogenesisThis section has been translated automatically.

Probably in apoptotic keratinocytes the alpha-helix structure of the keratins is transformed into a ß-leaf structure. These proteins cannot be cleared by macrophages and remain in the papillary dermis as keratinamyloid (detected by antibodies against keratin filaments). This explains the "high" dermal position of the amyloid deposits in the skin.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer