The ITGA3 gene (ITGA3 steth for Integrin Subunit Alpha 3) is a protein-coding gene located on chromosome 17q21.33. The gene encodes a member of the integrin alpha chain family.
ITGA3 Gene
DefinitionThis section has been translated automatically.
General informationThis section has been translated automatically.
Integrins are heterodimeric integral membrane proteins consisting of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded protein undergoes proteolytic processing to generate light and heavy chains that form the alpha-3 subunit. This subunit combines with a beta-1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family.
The encoded protein(CD49c), integrin alpha-3/beta-1, is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin, and CSPG4.
Integrin alpha-3/beta-1 provides a collagen-dependent docking site for FAP (Seprase) at the plasma membranes of invadopodia and may therefore be involved in adhesion, invadopodia formation, matrix degradation processes, and promote cell invasion. ITGA3 is a cell surface adhesion protein that interacts with extracellular matrix proteins involved in cancer metastasis.
Clinical pictureThis section has been translated automatically.
Diseases associated with ITGA3 include:
Epidermolysis Bullosa junctionalis with lung and kidney disease.
Pancreatic cancer: ITGA3 expression is increased in patients with pancreatic cancer. Evidence shows an association with histological type, histological grade, T classification and vital status. ITGA3 was further shown to have significant diagnostic value. High expression is correlated with poor overall survival (Jiao Y et al. 2019).
Breast cancer: ITGA3 has been identified as a novel biomarker for assessing the diagnosis and prognosis of breast cancer. . In addition, ITGA3 is involved in extracellular matrix regulation and immune cell infiltration (Li Y et al 2021).
LiteratureThis section has been translated automatically.
- Jiao Y et al (2019) ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer. Onco Targets Ther 12:4141-4152.
- Li Y et al (2021) ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer. Front Oncol 11:658547.