DefinitionThis section has been translated automatically.
The ITGA3 gene (ITGA3 steth for Integrin Subunit Alpha 3) is a protein-coding gene located on chromosome 17q21.33. The gene encodes a member of the integrin alpha chain family.
General informationThis section has been translated automatically.
Integrins are heterodimeric integral membrane proteins consisting of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded protein undergoes proteolytic processing to generate light and heavy chains that form the alpha-3 subunit. This subunit combines with a beta-1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family.
The encoded protein(CD49c), integrin alpha-3/beta-1, is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin, and CSPG4.
Integrin alpha-3/beta-1 provides a collagen-dependent docking site for FAP (Seprase) at the plasma membranes of invadopodia and may therefore be involved in adhesion, invadopodia formation, matrix degradation processes, and promote cell invasion. ITGA3 is a cell surface adhesion protein that interacts with extracellular matrix proteins involved in cancer metastasis.
Clinical pictureThis section has been translated automatically.
Diseases associated with ITGA3 include:
Epidermolysis Bullosa junctionalis with lung and kidney disease.
Pancreatic cancer: ITGA3 expression is increased in patients with pancreatic cancer. Evidence shows an association with histological type, histological grade, T classification and vital status. ITGA3 was further shown to have significant diagnostic value. High expression is correlated with poor overall survival (Jiao Y et al. 2019).
Breast cancer: ITGA3 has been identified as a novel biomarker for assessing the diagnosis and prognosis of breast cancer. . In addition, ITGA3 is involved in extracellular matrix regulation and immune cell infiltration (Li Y et al 2021).
LiteratureThis section has been translated automatically.
- Jiao Y et al (2019) ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer. Onco Targets Ther 12:4141-4152.
- Li Y et al (2021) ITGA3 Is Associated With Immune Cell Infiltration and Serves as a Favorable Prognostic Biomarker for Breast Cancer. Front Oncol 11:658547.
