Synonym(s)
beta-interferon-1a; IFN β-1a; IFN-β-1a; interferon-beta-1a; Interferon-β-1a; β-Interferon-1a
DefinitionThis section has been translated automatically.
IndicationThis section has been translated automatically.
Multiple sclerosis characterized by 2 or more relapses within the last 2 years.
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Limited indicationThis section has been translated automatically.
Severe kidney and liver damage, severe myelosuppression.
Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated.
Dosage and method of useThis section has been translated automatically.
- S.c. (Rebif): inject 44 µg of solution 3 times/week if higher dose is not tolerated Reduction to 22 µg s.c. 3 times/week
- I.m. (Avonex): 1 time/week 30 µg i.m.
Undesirable effectsThis section has been translated automatically.
Frequently flu-like general symptoms (fever, fatigue, chills, headaches, myalgia, sweating), reactions at the injection site (erythema)
ContraindicationThis section has been translated automatically.
Severe depression, suicidal tendency, epilepsy with seizures that cannot be sufficiently controlled therapeutically, Pat. < 16 LJ.
PreparationsThis section has been translated automatically.
Avonex, Rebif
Note(s)This section has been translated automatically.
Remember! No use together with other immunomodulators except glucocorticoids or ACTH. Caution is advised in case of comedication with substances which are primarily metabolised by the cytochrome P450 system (e.g. antiepileptic drugs).
Prof. Dr. med. Peter Altmeyer