Indomethacin

Definition
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Antirheumatic with weak analgesic and antipyretic effects. S.a.o. anti-inflammatory, non-steroidal.

Indication
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Chronic polyarthritis (rheumatoid arthritis), juvenile chronic arthritis, arthrosis, Bechterew's disease, acute infections of the locomotor system, gout attack, lumbalgia. sprains, strains. Post-operative pain, inflammation, swelling, dysmenorrhea.

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Dosage and method of use
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Adults: 2-3 times/day 25-50 mg p.o., if necessary slow dose increase. Recommended maximum dose: 200 mg indomethacin/day. The capsules or suspension should always be taken with meals.
Dose for children: Children from 2 years of age initial, divided into 2-3 doses, 1-3 mg/kg bw/day. This dose may be increased weekly to a maximum daily dose of 4 mg/kg bw or up to 150 to 200 mg/day, whichever is the lower daily dose of both. After improvement of symptoms reduction to the lowest possible maintenance dose.

Undesirable effects
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Very frequent or frequent gastrointestinal complaints such as gastritis, flatulence, dyspepsia as well as headaches, drowsiness, drowsiness, exhaustion. Rare exanthema, angioneurotic edema, petechiae or ecchymoses, purpura, alopecia, elevated transaminases.

Interactions
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Increased toxicity of ciclosporin, antihypertensive crises under phenylpropanolamine, increased plasma levels of indometacin with probenecid, delayed elimination of penicillin. Furosemide accelerates the excretion of indomethacin.