Synonym(s)
Non-specific immunoglobulins
DefinitionThis section has been translated automatically.
Drugs containing immunoglobulins, especially IgG, as antibodies.
IndicationThis section has been translated automatically.
Primary or secondary immunoglobulin deficiency syndrome, recurrent infections in immunocompromised patients, autoimmune thrombocytopenia in AIDS patients, see also IVIG.
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Dosage and method of useThis section has been translated automatically.
Intratect: Initially 0.4-0.8 g/kg bw, then 0.2-0.8 g/kg bw every 2-4 weeks to achieve an IgG blood level of at least 4-6 g/l.
Undesirable effectsThis section has been translated automatically.
Mostly harmless vasomotor disorders (headaches), fever, neutropenia, proteinuria, chills, allergic reactions up to anaphylactic shock, drop in blood pressure, dyspnoea, gastrointestinal disorders, sensation of heat, urticaria. Palmo-plantar and generalized eczematous reactions have also been described.
InteractionsThis section has been translated automatically.
The effect of live virus vaccines is reduced up to 3 months after immunoglobulin administration.
ContraindicationThis section has been translated automatically.
Hypersensitivity to immunoglobulins.
LiteratureThis section has been translated automatically.
- Vecchietti G et al (2006) Severe eczematous skin reaction after high-dose intravenous immunoglobulin infusion. Arch Dermatol 142: 213-217
Prof. Dr. med. Peter Altmeyer