Hyperplasia, focal epithelial B07

Heck, 1963; Archard, Heck and Stanley, 1965

Rare, warty, mucosa-colored papulesand plaques of the oral mucosa caused by human papillomaviruses (V.a. HPV types 13 u. 32; rare detection of HPV types 1,6,11). The disease is clustered in members of the Inuit and Native American populations in South America. In children: comorbidity with HIV infection is known.

Especially among Indians, South Americans and Asians. Less frequently in Europeans. Occasional familial clustering has also been described.

In larger studies > 85% of patients were HPV positive. HPV32 was detected in 50%, HPV6 in 30% and HPV40 in 5%. HPV32 but not HPV6 was detected in HIV infected patients.

Oral mucosa; mainly lip red (here on the mucosal side of the lower lip); corner of the mouth; cheek mucosa (about 65 % of patients); more rarely the floor of the mouth or the palate is affected.

Multiple wart-like, oral mucosa-coloured to whitish, persistent over months and years, broadly seated on the base, soft papules with a tendency to confluence. Size: 0,5-1,0 cm. Aggregation of the growths may result in larger, humpy beds.

Acanthosis with large ballooned cells in the stratum spinosum, papillomatosis. The retellions are extended and partly anastomosed. Mitosis figures in the stratum basale.

If necessary, excision or cauterization with subsequent curettage. Spontaneous healing possible. Successful local therapy with solutions containing vit. A-acid has been reported. A high spontaneous remission is guaranteed!

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