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Histoplasmosis, african B39.5
Definition This section has been translated automatically.
Rare form of histoplasmosis in Africa.
Pathogen This section has been translated automatically.
Histoplasma capsulatum var. duboisii
Occurrence/Epidemiology This section has been translated automatically.
Very rare and only sporadically in Europe. Prevalent in Madagascar and West and Central Africa.
Etiopathogenesis This section has been translated automatically.
Entry portal not yet secured (percutaneous, inhalation).
Clinic This section has been translated automatically.
Superficial subcutaneous granulomas with abscesses. Infection of the lymph nodes with fistulization is the rule.
Histology This section has been translated automatically.
Large, yeast-like fungal cells in tissue, giant tissue reaction, multinucleated giant cells, contain up to 30 fungal cells.
Internal therapy This section has been translated automatically.
Amphotericin B once/day 0.3-0.8 mg/kg bw i.v. for 6 weeks, creeping in at 0.25 mg/kg bw/day i.v.; if well tolerated, increase to the above dose as a continuous infusion over 4-6 hours. Side effects such as paresis, arachnoiditis or radiculitis can be alleviated by pre-injection of glucocorticoids. In mild forms of the disease, cotrimoxazole (e.g. Eusaprim forte) can also be given as a long-term therapy over 1 year. Ketoconazole (e.g. Nizoral) also seems to be effective.